Symbol
Name
ID

Mir146
microRNA 146
MGI:2676831

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Subacute progressive viral hepatitis	Autoimmunity
Disease(s) Associated with MIR146A	Subacute progressive viral hepatitis	Autoimmunity
hepatocellular carcinoma
type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

enlarged spleen

increased spleen weight

abnormal lymphopoiesis

myeloid hyperplasia

increased germinal center B cell number

increased plasma cell number

increased T follicular helper cell number

increased regulatory T cell number

decreased lymphocyte cell number

decreased monocyte cell number

decreased leukocyte cell number

abnormal spleen B cell follicle morphology

increased spleen germinal center number

increased spleen germinal center size

increased IgG1 level

increased IgG level

abnormal T cell activation

abnormal regulatory T cell physiology

abnormal macrophage physiology

increased macrophage nitric oxide production

increased circulating interleukin-1 beta level

increased circulating interleukin-10 level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level

enlarged lymph nodes

abnormal immune system physiology

decreased interferon-gamma secretion

increased interleukin-1 beta secretion

increased interleukin-6 secretion

increased tumor necrosis factor secretion

abnormal immune tolerance

increased anti-double stranded DNA antibody level

increased acute inflammation

increased susceptibility to endotoxin shock

increased susceptibility to bacterial infection induced morbidity/mortality

Availability

Mouse Genotype

Mir146^tm1.1Bal/Mir146^tm1.1Bal

Mir146^tm2.1Bal/Mir146^tm2.1Bal

Mir146^tm1.1Lfl/Mir146^tm1.1Lfl
Tg(Cr2-cre)3Cgn/0 (conditional)

Mir146^tm1.1Lfl/Mir146^tm1.1Lfl
Ighg1^tm1(cre)Cgn/Ighg1⁺ (conditional)

Mir146^tm1.1Lfl/Mir146^tm1.1Lfl
Tg(CD2-icre)4Kio/0 (conditional)

Mir146^tm1.1Lfl/Mir146^tm1.1Lfl
Tg(Cd4-cre)1Cwi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23